Myeloid leukocyte migration

Across TCGA patient cohorts, RNA activity of the Myeloid leukocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BIN2, VSIG4, and MIR223HG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid leukocyte migration activity versus BIN2 in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BIN2 →	+0.802	+0.240	.001	<.001	3	6
BRCA	VSIG4 →	+1.011	+0.230	<.001	<.001	3	6
UCEC	MIR223HG →	+1.147	+0.230	.002	.001	3	6
BRCA	GMFG →	+0.717	+0.204	<.001	<.001	3	6
OV	PIK3R5 →	+0.649	+0.196	<.001	<.001	3	6
HNSC	LCP2 →	+0.960	+0.187	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097529 vs BIN2 — OV

Explore this scatter interactively →