Necroptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Necroptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR8, ATP8B4, and SIGLEC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Necroptotic signaling pathway activity versus TLR8 in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TLR8 →	+0.655	+0.383	<.001	<.001	3	5
GBM	ATP8B4 →	+0.473	+0.415	<.001	<.001	3	5
GBM	SIGLEC9 →	+0.736	+0.441	<.001	<.001	3	5
GBM	CAMSAP1 →	-0.406	-0.421	<.001	<.001	3	5
GBM	GPR84 →	+1.071	+0.420	<.001	<.001	3	5
GBM	FCGR1A →	+0.664	+0.489	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097527 vs TLR8 — GBM

Explore this scatter interactively →