Necroptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Necroptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, ZNF300, and CEACAM19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB8 grouped by Necroptotic signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PSMB8 →	+2.738	+1.182	.002	.004	3	5
STOMACH	ZNF300 →	+2.265	+1.247	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CEACAM19 →	+1.024	+1.148	.009	.001	3	4
LUNG_NSCLC_LUSC	PSMB9 →	+2.780	+1.104	.001	.009	3	4
LIVER	DHX58 →	+1.450	+1.604	.008	<.001	3	4
LIVER	APOL6 →	+1.860	+1.346	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB8 by Necroptotic signaling pathway activity — LIVER

Explore this box plot interactively →