Necroptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Necroptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL11A, SPAG7, and LYSMD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Necroptotic signaling pathway activity versus BCL11A in LARGE_INTESTINE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCL11A →	-2.508	-0.321	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SPAG7 →	+0.959	+0.353	<.001	<.001	3	3
BLOOD_Lymphoma	LYSMD2 →	+2.208	+0.469	<.001	<.001	3	3
BLOOD_Lymphoma	FAS →	+2.805	+0.545	.002	<.001	3	3
CNS	ZNF572 →	-0.404	-0.534	.009	.001	2	4
KIDNEY	ADAP2 →	+2.572	+0.653	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097527 vs BCL11A — LARGE_INTESTINE

Explore this scatter interactively →