Mannosylation

pathway activity — cross-omics
GO:0097502Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mannosylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SQOR, UBASH3B, and PARP14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCSQOR →-0.401-0.046<.001<.00137
BRCAUBASH3B →-0.374-0.027<.001.00137
BRCAPARP14 →-0.451-0.037<.001<.00137
BRCAFERMT3 →-0.399-0.038<.001<.00137
BRCAGMIP →-0.271-0.040.001<.00137
LSCCINPP5D →-0.339-0.041<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration