Mannosylation

pathway activity — cross-omics
GO:0097502Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mannosylation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD12, CASQ2, and NAALADL2-AS3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACANKRD12 →-0.369-0.592.002.00333
PDACCASQ2 →-0.612-0.648.002.00133
LUADNAALADL2-AS3 →+0.953+0.891<.001<.00133
LSCCRPL32P21 →-0.191-0.621<.001.00632
LSCCSNORD113-9 →+0.898+0.541<.001.00532
LSCCLINC01460 →-0.487-0.871.003.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration