Receptor localization to non-motile cilium

Across TCGA patient cohorts, RNA activity of the Receptor localization to non-motile cilium pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PEBP1, NRDC, and DNM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor localization to non-motile cilium activity versus PEBP1 in CCRCC (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PEBP1 →	+0.320	+0.049	.005	.001	3	7
OV	NRDC →	-0.347	-0.067	<.001	.001	3	7
HNSC	DNM1 →	+0.439	+0.065	<.001	.001	3	6
HNSC	DPYSL2 →	+0.257	+0.065	.005	<.001	3	6
PDAC	FASN_S207 →	-0.555	-0.066	<.001	<.001	3	6
UCEC	LMNA →	+0.552	+0.120	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097500 vs PEBP1 — CCRCC

Explore this scatter interactively →