Regulation of vesicle size

Across TCGA patient cohorts, RNA activity of the Regulation of vesicle size pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SASH3_S97, SEPTIN4_S117, and SEPTIN4_S432, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vesicle size activity versus SASH3_S97 in LUAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SASH3_S97 →	+0.650	+0.035	.001	<.001	3	6
GBM	SEPTIN4_S117 →	+0.843	+0.031	.003	.003	3	6
GBM	SEPTIN4_S432 →	+0.824	+0.042	<.001	.001	3	6
PDAC	SPN_S355 →	+0.654	+0.036	<.001	<.001	3	6
LUAD	RSU1 →	+0.274	+0.037	<.001	<.001	3	6
GBM	CTSZ →	+0.510	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097494 vs SASH3_S97 — LUAD

Explore this scatter interactively →