Regulation of vesicle size

Across TCGA patient cohorts, RNA activity of the Regulation of vesicle size pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYW1, CYB5R3, and BCL2L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vesicle size activity versus TYW1 in CCRCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TYW1 →	+0.213	+0.190	.007	.001	3	4
PDAC	CYB5R3 →	+0.379	+0.250	<.001	<.001	3	4
GBM	BCL2L1 →	+0.500	+0.170	<.001	.009	3	3
CCRCC	RBM19 →	+0.222	+0.222	.004	<.001	3	3
CCRCC	GLYR1 →	+0.253	+0.238	.001	.001	3	3
CCRCC	KCTD18 →	+0.284	+0.245	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097494 vs TYW1 — CCRCC

Explore this scatter interactively →