Dendrite extension

Across TCGA patient cohorts, RNA activity of the Dendrite extension pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPM4, ARFGEF3, and PHLDB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite extension activity versus TPM4 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPM4 →	-0.273	-0.057	<.001	<.001	3	6
HNSC	ARFGEF3 →	+0.648	+0.047	<.001	<.001	3	6
HNSC	PHLDB1 →	-0.267	-0.045	.006	<.001	3	6
GBM	TLN1 →	-0.284	-0.062	<.001	<.001	3	6
LSCC	CBX8 →	+0.363	+0.052	<.001	<.001	3	6
BRCA	CAPZA1 →	-0.239	-0.032	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097484 vs TPM4 — GBM

Explore this scatter interactively →