Dendrite extension

Across TCGA cell cohorts, RNA activity of the Dendrite extension pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA3A, ZNF486, and ACADVL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEMA3A grouped by Dendrite extension-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SEMA3A →	+1.844	+0.329	.002	.007	2	5
LIVER	ZNF486 →	+1.803	+1.883	.003	<.001	3	3
OESOPHAGUS	ACADVL →	+1.213	+0.491	<.001	<.001	3	3
OESOPHAGUS	LCA5 →	+1.101	+0.491	.001	<.001	3	3
BLOOD_Myeloma	AHI1 →	+0.804	+1.634	.004	.004	2	4
OESOPHAGUS	NAA80 →	+0.935	+0.491	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEMA3A by Dendrite extension activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →