Dendrite extension

Across TCGA cell cohorts, RNA activity of the Dendrite extension pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDC80, NCAPG, and CDCA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendrite extension activity versus NDC80 in LUNG_NSCLC_LUAD (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NDC80 →	-0.909	-0.247	.001	<.001	3	4
BLOOD_Leukemia	NCAPG →	-1.074	-0.291	<.001	<.001	3	4
BLOOD_Leukemia	CDCA3 →	-0.889	-0.282	.002	.001	3	4
LARGE_INTESTINE	B3GAT2 →	-0.199	-0.201	.002	.003	3	4
LUNG_NSCLC_LUAD	DEK →	-0.735	-0.206	.002	.001	3	3
LUNG_NSCLC_LUAD	TACC3 →	-0.735	-0.208	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097484 vs NDC80 — LUNG_NSCLC_LUAD

Explore this scatter interactively →