Motor neuron migration

Across TCGA patient cohorts, RNA activity of the Motor neuron migration pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZCCHC24, ZYX, and CCDC50, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor neuron migration activity versus ZCCHC24 in COAD (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZCCHC24 →	-0.472	-0.049	.001	.001	2	7
COAD	ZYX →	-0.325	-0.042	.001	.003	3	6
COAD	CCDC50 →	-0.312	-0.054	<.001	<.001	3	6
LSCC	CHTF18 →	+0.442	+0.094	<.001	<.001	3	6
LSCC	CNRIP1 →	-0.350	-0.060	<.001	.001	3	6
CCRCC	ENO2 →	+0.668	+0.073	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097475 vs ZCCHC24 — COAD

Explore this scatter interactively →