Motor neuron migration

Across TCGA patient cohorts, RNA activity of the Motor neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLT1, FAM240C, and MIR744, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor neuron migration activity versus FLT1 in LUAD (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FLT1 →	+0.680	+0.774	<.001	<.001	3	4
LSCC	FAM240C →	-0.430	-0.559	.002	.002	3	3
LSCC	MIR744 →	+0.366	+0.443	.007	.003	2	4
LUAD	FAM3C →	+0.540	+0.496	<.001	<.001	3	3
LUAD	COL11A1 →	+1.529	+0.475	.001	.008	3	3
PDAC	ASB18 →	+0.075	+0.421	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097475 vs FLT1 — LUAD

Explore this scatter interactively →