Motor neuron migration

Across TCGA cell cohorts, RNA activity of the Motor neuron migration pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRNB1, MDC1, and LRRC42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHRNB1 grouped by Motor neuron migration-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CHRNB1 →	-2.303	-1.687	.003	<.001	3	5
SOFT_TISSUE	MDC1 →	-0.915	-1.278	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	LRRC42 →	-1.000	-1.734	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	LAMC1 →	-1.455	-1.334	.004	.004	3	4
UPPER_AERODIGESTIVE_TRACT	OSBPL10 →	-1.043	-1.558	.007	.005	3	4
UPPER_AERODIGESTIVE_TRACT	IL31RA →	-1.760	-1.316	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHRNB1 by Motor neuron migration activity — OESOPHAGUS

Explore this box plot interactively →