Programmed cell death in response to reactive oxygen species

Across TCGA patient cohorts, RNA activity of the Programmed cell death in response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB14, TBX2, and RN7SL455P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Programmed cell death in response to reactive oxygen species activity versus RAB14 in LUAD (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAB14 →	+0.210	+0.068	.002	.008	3	3
CCRCC	TBX2 →	+0.763	+0.125	.005	.008	3	3
LSCC	RN7SL455P →	-0.352	-0.284	.001	.002	3	3
GBM	PAWR →	+0.620	+0.183	.001	.004	3	3
PDAC	MET →	+0.801	+0.164	<.001	<.001	3	3
UCEC	OLFM1 →	+0.574	+0.321	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097468 vs RAB14 — LUAD

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