Programmed cell death in response to reactive oxygen species

Across TCGA cell cohorts, RNA activity of the Programmed cell death in response to reactive oxygen species pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP2, SEMA7A, and ECI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP2 grouped by Programmed cell death in response to reactive oxygen species-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IGFBP2 →	+1.796	+0.791	.005	<.001	3	4
BREAST	SEMA7A →	-1.320	-0.808	.001	<.001	3	4
BREAST	ECI1 →	+0.881	+0.921	<.001	.008	3	4
BREAST	PAM16 →	+0.576	+1.015	.006	<.001	2	5
LUNG_SCLC	GPR176 →	-2.721	-1.552	<.001	.002	3	3
BREAST	TIMP2 →	-2.680	-0.908	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP2 by Programmed cell death in response to reactive oxygen species activity — BREAST

Explore this box plot interactively →