Liver regeneration

Across TCGA patient cohorts, RNA activity of the Liver regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, UTP15, and WDR43, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Liver regeneration activity versus RRM2 in GBM (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRM2 →	+0.638	+0.048	<.001	<.001	3	9
UCEC	UTP15 →	+0.321	+0.056	<.001	<.001	3	9
LSCC	WDR43 →	+0.284	+0.064	<.001	<.001	3	9
GBM	MAD2L1 →	+0.570	+0.057	<.001	<.001	3	9
LUAD	MCM2_S139 →	+0.630	+0.048	<.001	<.001	3	9
LSCC	RIF1 →	+0.587	+0.086	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097421 vs RRM2 — GBM

Explore this scatter interactively →