Liver regeneration

Across TCGA patient cohorts, RNA activity of the Liver regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF11, TRIP13, and HELLS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Liver regeneration activity versus KIF11 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF11 →	+0.917	+0.240	<.001	<.001	3	6
LSCC	TRIP13 →	+0.851	+0.196	.001	.001	3	6
LSCC	HELLS →	+0.514	+0.173	<.001	<.001	3	5
BRCA	HROB →	+0.615	+0.237	<.001	.003	3	5
LSCC	FAM83D →	+1.202	+0.240	<.001	.001	3	5
LSCC	CDC20 →	+0.495	+0.165	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097421 vs KIF11 — LSCC

Explore this scatter interactively →