Neuroblast migration

pathway activity — cross-omics
GO:0097402Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Neuroblast migration pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHGA, BCAS4, and METTL16, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCCHGA →+1.196+0.144.003.00632
LSCCBCAS4 →+0.660+0.129.002.00332
LSCCMETTL16 →+0.588+0.182.005.00432
LSCCLRFN1 →+0.695+0.195.001<.00132
LSCCZNF18 →+0.628+0.183.007<.00132
LSCCVPS11 →+0.514+0.145.002.00632
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration