Synaptic vesicle lumen acidification

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle lumen acidification pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASAH1, ATP6V1B2, and GNPTG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle lumen acidification activity versus ASAH1 in SKIN (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ASAH1 →	+2.624	+0.737	<.001	.009	3	5
LUNG_SCLC	ATP6V1B2 →	+0.633	+0.198	.004	.002	3	5
BLOOD_Leukemia	GNPTG →	+0.580	+0.471	<.001	.009	3	4
CNS	CNIH3 →	+2.128	+0.271	.004	<.001	3	4
LUNG_SCLC	CLCN7 →	+0.713	+0.253	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	VPS35L →	+1.639	+1.569	.004	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097401 vs ASAH1 — SKIN

Explore this scatter interactively →