Interleukin-17-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-17-mediated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP9, RASSF5, and PYCARD, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-17-mediated signaling pathway activity versus ARHGAP9 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARHGAP9 →	+0.502	+0.066	<.001	<.001	3	8
CCRCC	RASSF5 →	+0.373	+0.093	.001	<.001	3	7
CCRCC	PYCARD →	+0.501	+0.088	<.001	<.001	3	7
GBM	SYK →	+0.468	+0.086	<.001	<.001	3	7
GBM	NFATC2 →	+0.320	+0.069	.002	<.001	3	7
GBM	SPN →	+0.519	+0.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097400 vs ARHGAP9 — GBM

Explore this scatter interactively →