Interleukin-17-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Interleukin-17-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SURF2, RNA5SP170, and RECQL5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-17-mediated signaling pathway activity versus SURF2 in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SURF2 →	+0.449	+0.515	.004	.007	3	3
LSCC	RNA5SP170 →	+0.473	+0.553	<.001	<.001	3	3
BRCA	RECQL5 →	+0.656	+0.452	<.001	.006	3	3
BRCA	NDOR1 →	+0.499	+0.388	.009	.002	3	3
CCRCC	UVSSA →	+0.286	+0.435	.002	<.001	3	3
CCRCC	PTPN23 →	+0.351	+0.493	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097400 vs SURF2 — OV

Explore this scatter interactively →