Interleukin-17-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-17-mediated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBL2, LONRF2, and RFX3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBL2 grouped by Interleukin-17-mediated signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RBL2 →	+0.171	+0.151	.007	.002	3	3
LUNG_NSCLC_LUAD	LONRF2 →	+0.240	+0.170	.007	.001	3	3
BLOOD_Leukemia	RFX3 →	+0.211	+0.233	<.001	<.001	3	2
PANCREAS	SDF4 →	-0.324	-0.343	<.001	.008	2	3
OVARY	DLK2 →	+0.210	+0.347	.001	.002	3	2
OVARY	EFCAB6 →	+0.393	+0.383	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBL2 by Interleukin-17-mediated signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →