Interleukin-17-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Interleukin-17-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT3, STK38, and BRIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Interleukin-17-mediated signaling pathway activity versus CCT3 in BLOOD_Lymphoma (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCT3 →	+1.187	+0.129	<.001	.003	3	4
OESOPHAGUS	STK38 →	-1.178	-0.167	.004	.001	3	3
OESOPHAGUS	BRIP1 →	-1.106	-0.155	.008	.003	3	3
OESOPHAGUS	ITPRID2 →	-0.444	-0.134	<.001	.004	3	3
SOFT_TISSUE	SF3B1 →	-0.745	-0.156	.002	.006	3	3
BLOOD_Lymphoma	RAPGEFL1 →	-1.288	-0.136	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097400 vs CCT3 — BLOOD_Lymphoma

Explore this scatter interactively →