Response to interleukin-17

Across TCGA patient cohorts, RNA activity of the Response to interleukin-17 pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD3, FMNL1, and MYO1G, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-17 activity versus AMPD3 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AMPD3 →	+0.696	+0.116	<.001	<.001	3	9
GBM	FMNL1 →	+0.521	+0.111	<.001	<.001	3	9
CCRCC	MYO1G →	+0.559	+0.125	<.001	<.001	3	9
GBM	NCF2 →	+0.538	+0.091	<.001	<.001	3	9
GBM	ICAM1 →	+0.548	+0.083	<.001	<.001	3	9
GBM	ARHGAP30 →	+0.496	+0.089	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097396 vs AMPD3 — GBM

Explore this scatter interactively →