Response to interleukin-17

Across TCGA cell cohorts, RNA activity of the Response to interleukin-17 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FTH1, TMEM120A, and BST2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-17 activity versus FTH1 in BLOOD_Lymphoma (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FTH1 →	-1.261	-0.140	.006	.008	3	4
BLOOD_Myeloma	TMEM120A →	-0.652	-0.157	.004	.007	3	4
KIDNEY	BST2 →	-4.989	-0.222	<.001	<.001	3	4
SOFT_TISSUE	NOTCH1 →	-1.914	-0.228	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	C4orf33 →	-0.863	-0.220	.002	.003	3	4
PANCREAS	ALKBH7 →	+1.013	+0.214	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097396 vs FTH1 — BLOOD_Lymphoma

Explore this scatter interactively →