Chorionic trophoblast cell proliferation

pathway activity — cross-omics
GO:0097360Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Chorionic trophoblast cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAPN5, CLINT1, and CMBL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACCAPN5 →+0.527+0.114.002<.00136
COADCLINT1 →+0.294+0.079<.001<.00136
COADCMBL →+0.608+0.085<.001<.00136
CCRCCCTHRC1 →-0.748-0.116<.001<.00136
COADPLEKHA7 →+0.351+0.072<.001<.00136
COADEMILIN2 →-0.470-0.062<.001.00326
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration