Prenylation

Across TCGA patient cohorts, RNA activity of the Prenylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP5P1, MAPK10, and PRSS12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prenylation activity versus DUSP5P1 in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DUSP5P1 →	+0.411	+0.080	.006	.001	3	3
UCEC	MAPK10 →	-0.968	-0.257	<.001	<.001	2	4
UCEC	PRSS12 →	-0.816	-0.206	.005	.001	3	3
UCEC	PHKG1 →	-0.596	-0.240	<.001	.001	3	3
UCEC	RN7SL138P →	-0.856	-0.200	<.001	.001	3	3
GBM	FOLR1 →	-0.853	-0.196	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097354 vs DUSP5P1 — CCRCC

Explore this scatter interactively →