Prenylation

Across TCGA cell cohorts, RNA activity of the Prenylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFI1B, PLPP6, and PDPK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prenylation activity versus GFI1B in BLOOD_Leukemia (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFI1B →	+3.266	+0.264	.005	.008	3	4
OVARY	PLPP6 →	+1.505	+0.592	<.001	.005	2	5
BREAST	PDPK1 →	+0.459	+0.379	.001	<.001	3	4
LIVER	ARL14EP →	+0.663	+0.595	<.001	<.001	3	4
SOFT_TISSUE	RABGGTB →	+1.179	+0.518	.001	.001	3	3
OESOPHAGUS	PLLP →	+2.824	+0.575	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097354 vs GFI1B — BLOOD_Leukemia

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