Autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Autophagosome maturation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL10A, and SERBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome maturation activity versus RPL5 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.215	-0.024	.003	.003	3	8
BRCA	RPL10A →	-0.241	-0.032	.001	<.001	3	7
COAD	SERBP1 →	-0.210	-0.024	<.001	<.001	3	7
LUAD	RFC1_S368 →	-0.608	-0.029	.002	.002	3	6
PDAC	RPS2 →	-0.201	-0.036	.001	<.001	3	6
LSCC	SHROOM4_S299 →	+0.659	+0.051	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097352 vs RPL5 — BRCA

Explore this scatter interactively →