Autophagosome maturation

Across TCGA patient cohorts, RNA activity of the Autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM50, RNF24, and SAMSN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome maturation activity versus TIMM50 in UCEC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM50 →	-0.438	-0.195	.003	<.001	3	5
HNSC	RNF24 →	-0.507	-0.116	<.001	.005	3	4
LUAD	SAMSN1 →	+0.535	+0.137	.001	.003	3	4
UCEC	AIMP1 →	-0.281	-0.146	.006	.003	3	4
BRCA	CDK5RAP1 →	-0.398	-0.175	.002	.001	3	4
LSCC	NUP93 →	-0.384	-0.113	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097352 vs TIMM50 — UCEC

Explore this scatter interactively →