Autophagosome maturation

Across TCGA cell cohorts, RNA activity of the Autophagosome maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LONRF3, MAGIX, and GDE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Autophagosome maturation activity versus LONRF3 in LUNG_NSCLC_LUSC (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LONRF3 →	+2.035	+0.417	.007	.002	3	5
LUNG_NSCLC_LUSC	MAGIX →	+0.705	+0.466	.002	<.001	3	5
BREAST	GDE1 →	+0.903	+0.204	.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	PRKACB →	+0.902	+0.203	.003	.004	3	5
UPPER_AERODIGESTIVE_TRACT	DBI →	+1.576	+0.185	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	APOO →	+0.727	+0.186	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097352 vs LONRF3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →