Mitochondrial outer membrane permeabilization

Across TCGA patient cohorts, RNA activity of the Mitochondrial outer membrane permeabilization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SARAF, C18orf54, and BIRC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial outer membrane permeabilization activity versus SARAF in CCRCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SARAF →	+0.298	+0.176	.002	.001	3	5
GBM	C18orf54 →	-0.627	-0.184	<.001	<.001	3	5
LUAD	BIRC5 →	-0.986	-0.203	<.001	<.001	3	5
UCEC	SGO2 →	-0.570	-0.237	.002	<.001	3	5
HNSC	XYLT1 →	-0.634	-0.167	.001	.003	3	4
CCRCC	ANKRD42 →	+0.370	+0.215	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097345 vs SARAF — CCRCC

Explore this scatter interactively →