Mitochondrial outer membrane permeabilization

Across TCGA cell cohorts, RNA activity of the Mitochondrial outer membrane permeabilization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MKKS, BCR, and CEMIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MKKS grouped by Mitochondrial outer membrane permeabilization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MKKS →	+1.251	+1.499	.003	<.001	3	4
PANCREAS	BCR →	-0.611	-1.274	.009	<.001	3	4
OVARY	CEMIP2 →	-1.044	-1.055	.004	<.001	3	4
OVARY	SLTM →	-0.665	-1.152	.006	.007	3	4
SOFT_TISSUE	UNC50 →	-0.337	-1.456	.004	.004	3	4
BONE	BSG →	-0.600	-1.409	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MKKS by Mitochondrial outer membrane permeabilization activity — PANCREAS

Explore this box plot interactively →