Melanocyte proliferation

Across TCGA patient cohorts, RNA activity of the Melanocyte proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL1A1, FILIP1L, and FKBP7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Melanocyte proliferation activity versus COL1A1 in CCRCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COL1A1 →	+0.953	+0.107	<.001	<.001	3	9
UCEC	FILIP1L →	+0.763	+0.102	<.001	<.001	3	9
OV	FKBP7 →	+0.547	+0.083	<.001	.001	3	9
BRCA	OLFML3 →	+1.019	+0.093	<.001	<.001	3	9
HNSC	PCOLCE →	+0.781	+0.175	<.001	<.001	3	9
UCEC	PDLIM7 →	+0.646	+0.088	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097325 vs COL1A1 — CCRCC

Explore this scatter interactively →