Melanocyte proliferation

Across TCGA cell cohorts, RNA activity of the Melanocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALGPS1, MMP19, and FRAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RALGPS1 grouped by Melanocyte proliferation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RALGPS1 →	+1.193	+1.891	.006	.001	3	4
URINARY_TRACT	MMP19 →	-3.593	-2.033	<.001	<.001	2	5
LARGE_INTESTINE	FRAT2 →	+0.930	+0.764	<.001	<.001	3	4
BREAST	STK36 →	+0.822	+0.881	.005	.003	3	3
BREAST	SFI1 →	+1.006	+0.917	.006	.006	3	3
LUNG_SCLC	SESN3 →	-3.361	-1.493	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RALGPS1 by Melanocyte proliferation activity — BLOOD_Myeloma

Explore this box plot interactively →