Melanocyte proliferation

Across TCGA cell cohorts, RNA activity of the Melanocyte proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFY, LRP2, and TAF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFY grouped by Melanocyte proliferation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZFY →	-0.269	-1.178	<.001	.003	3	5
OESOPHAGUS	LRP2 →	+0.173	+1.634	.004	.004	3	4
UPPER_AERODIGESTIVE_TRACT	TAF11 →	-0.197	-1.600	.004	.001	3	3
LARGE_INTESTINE	UBA2 →	-0.509	-1.773	.003	<.001	3	3
LARGE_INTESTINE	ESD →	-0.293	-1.321	.007	.008	3	3
LARGE_INTESTINE	ZNF222 →	-0.201	-1.159	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFY by Melanocyte proliferation activity — LARGE_INTESTINE

Explore this box plot interactively →