Cellular response to alcohol

Across TCGA patient cohorts, RNA activity of the Cellular response to alcohol pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADH1B, DAB2, and RRP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to alcohol activity versus ADH1B in OV (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ADH1B →	+1.338	+0.040	.003	<.001	3	7
OV	DAB2 →	+0.322	+0.031	.003	.001	3	7
BRCA	RRP1 →	-0.407	-0.024	.001	.001	3	7
BRCA	CNRIP1 →	+0.571	+0.028	<.001	<.001	3	7
BRCA	GAS7 →	+0.398	+0.025	<.001	<.001	3	7
OV	LUM →	+0.724	+0.034	.005	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097306 vs ADH1B — OV

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