Cellular response to alcohol

Across TCGA cell cohorts, RNA activity of the Cellular response to alcohol pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THYN1, COMMD4, and ZNF446, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, THYN1 grouped by Cellular response to alcohol-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	THYN1 →	-1.084	-0.207	.009	.002	3	4
PANCREAS	COMMD4 →	-0.519	-0.186	<.001	.002	2	5
BLOOD_Leukemia	ZNF446 →	-0.624	-0.213	.004	.002	2	4
URINARY_TRACT	ACTL6A →	-0.942	-0.285	.005	.002	3	3
BONE	EID3 →	-0.711	-0.226	.003	.002	3	3
LARGE_INTESTINE	DDHD1 →	-0.830	-0.135	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THYN1 by Cellular response to alcohol activity — BONE

Explore this box plot interactively →