Response to alcohol

Across TCGA patient cohorts, RNA activity of the Response to alcohol pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NARS2, LRPPRC, and NIF3L1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to alcohol activity versus NARS2 in COAD (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NARS2 →	-0.353	-0.174	.005	.002	3	2
COAD	LRPPRC →	-0.339	-0.110	<.001	.004	3	2
COAD	NIF3L1 →	-0.379	-0.163	.009	.001	3	2
COAD	HMGB1P21 →	+0.253	+0.158	<.001	<.001	3	2
COAD	RN7SL648P →	+0.316	+0.167	.004	<.001	3	2
BRCA	ACADL →	+0.903	+0.288	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097305 vs NARS2 — COAD

Explore this scatter interactively →