Response to alcohol

Across TCGA cell cohorts, RNA activity of the Response to alcohol pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PET100, ACY1, and SEMA6C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PET100 grouped by Response to alcohol-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PET100 →	-0.772	-0.157	.003	.005	3	6
UPPER_AERODIGESTIVE_TRACT	ACY1 →	+0.734	+0.173	.008	.005	3	5
BLOOD_Leukemia	SEMA6C →	-2.449	-0.155	.001	.003	3	4
LUNG_SCLC	NRL →	-0.517	-0.113	.002	.003	3	4
LARGE_INTESTINE	CTSD →	+1.124	+0.092	.003	<.001	3	4
LARGE_INTESTINE	ARHGAP1 →	+0.810	+0.089	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PET100 by Response to alcohol activity — URINARY_TRACT

Explore this box plot interactively →