Response to alcohol

Across TCGA cell cohorts, RNA activity of the Response to alcohol pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL6R, ABCA3, and SLC9A3R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to alcohol activity versus IL6R in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IL6R →	+0.969	+0.153	.004	<.001	3	4
CNS	ABCA3 →	+1.944	+0.154	.003	.003	3	4
LIVER	SLC9A3R1 →	+2.048	+0.181	<.001	.002	3	4
STOMACH	NME7 →	-0.928	-0.161	<.001	.001	3	4
LUNG_NSCLC_LUAD	AGFG2 →	+0.783	+0.123	.001	.008	3	4
LUNG_NSCLC_LUAD	MYORG →	+1.287	+0.192	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097305 vs IL6R — OESOPHAGUS

Explore this scatter interactively →