Programmed necrotic cell death

Across TCGA patient cohorts, RNA activity of the Programmed necrotic cell death pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAS, TRIM21, and SHFL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Programmed necrotic cell death activity versus FAS in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAS →	+0.567	+0.046	<.001	<.001	3	8
HNSC	TRIM21 →	+0.655	+0.063	<.001	<.001	3	8
LSCC	SHFL →	+0.292	+0.065	<.001	<.001	3	7
LSCC	INPP1 →	+0.475	+0.048	<.001	<.001	3	7
LSCC	NFKB1 →	+0.285	+0.069	<.001	<.001	3	7
BRCA	LGALS9 →	+0.608	+0.051	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097300 vs FAS — GBM

Explore this scatter interactively →