Programmed necrotic cell death

Across TCGA patient cohorts, RNA activity of the Programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRHL2, MTA3, and PPP2R3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Programmed necrotic cell death activity versus GRHL2 in LSCC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GRHL2 →	-0.640	-0.222	.003	<.001	3	5
GBM	MTA3 →	-0.342	-0.128	<.001	<.001	3	5
GBM	PPP2R3B →	-0.661	-0.211	<.001	<.001	3	4
PDAC	LAIR2 →	+0.565	+0.110	.002	<.001	3	4
LSCC	CD300LF →	+0.724	+0.268	<.001	<.001	3	4
CCRCC	NEURL1B →	-0.730	-0.163	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097300 vs GRHL2 — LSCC

Explore this scatter interactively →