Programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Programmed necrotic cell death pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMTC3, SLC7A14, and CETN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMTC3 grouped by Programmed necrotic cell death-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TMTC3 →	-0.941	-1.304	.004	.002	3	4
LUNG_SCLC	SLC7A14 →	+2.001	+0.843	.007	.008	3	4
CNS	CETN2 →	+0.682	+0.739	.001	.007	3	4
PANCREAS	TM2D1 →	-0.632	-1.075	.002	.003	3	4
SKIN	FLNA →	+0.597	+0.653	.007	.008	3	4
SKIN	IRAK4 →	-0.476	-0.701	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMTC3 by Programmed necrotic cell death activity — SOFT_TISSUE

Explore this box plot interactively →