Programmed necrotic cell death

Across TCGA cell cohorts, RNA activity of the Programmed necrotic cell death pathway is significantly associated with the protein abundance of multiple proteins, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPIF, DYNC1H1, and TUBA4B, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Programmed necrotic cell death activity versus PPIF in KIDNEY (Pearson r = 0.84).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPIF →	+1.518	+0.665	<.001	.001	3	19
URINARY_TRACT	DYNC1H1 →	-2.007	-1.289	<.001	.005	3	15
URINARY_TRACT	TUBA4B →	-2.708	-0.814	<.001	.008	3	15
SKIN	UPF1 →	-0.650	-0.321	<.001	<.001	3	15
URINARY_TRACT	CAPNS1 →	-2.151	-0.824	.002	.007	3	14
URINARY_TRACT	PSMB1 →	-1.553	-1.147	<.001	.005	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097300 vs PPIF — KIDNEY

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