XMP metabolic process

Across TCGA patient cohorts, RNA activity of the XMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAICS, TAF4B, and CENPH, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, XMP metabolic process activity versus PAICS in LSCC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PAICS →	+0.647	+0.198	.003	.001	3	6
UCEC	TAF4B →	+0.814	+0.135	.001	<.001	3	6
UCEC	CENPH →	+0.758	+0.107	<.001	.001	3	6
OV	HMGB2 →	+0.523	+0.105	.005	.002	3	6
LSCC	CD63 →	-0.398	-0.202	.001	.001	3	5
CCRCC	G2E3 →	+0.233	+0.136	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097292 vs PAICS — LSCC

Explore this scatter interactively →