XMP metabolic process

Across TCGA cell cohorts, RNA activity of the XMP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF7L1, FUT4, and MSRB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCF7L1 grouped by XMP metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TCF7L1 →	-0.836	-0.331	.008	.001	2	5
KIDNEY	FUT4 →	+0.800	+0.415	<.001	<.001	3	4
STOMACH	MSRB3 →	-2.368	-0.532	<.001	.005	3	4
STOMACH	ST6GALNAC1 →	+3.420	+0.329	<.001	<.001	3	4
CNS	TMEM87B →	+0.583	+0.554	.003	.001	3	4
OVARY	MAPK13 →	+2.246	+0.995	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCF7L1 by XMP metabolic process activity — KIDNEY

Explore this box plot interactively →