Hepatocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Hepatocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSN, SEPTIN8, and TMEM123, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hepatocyte apoptotic process activity versus GSN in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSN →	+2.035	+0.299	.001	.004	3	5
PANCREAS	SEPTIN8 →	+0.667	+1.209	.003	.004	3	5
OESOPHAGUS	TMEM123 →	+2.033	+1.439	.001	<.001	3	4
OESOPHAGUS	C5orf63 →	+1.344	+1.334	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	CFLAR →	+2.505	+1.726	<.001	<.001	3	4
STOMACH	MRPS22 →	+0.792	+1.117	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097284 vs GSN — BLOOD_Leukemia

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